Episodes
Charles Duhigg Lost 45 Lbs on a GLP-1 | Why Food Noise Vanishes
Charles Duhigg joins James to explain why GLP-1 drugs may do more than suppress appetite. They talk about “food noise,” habit loops, keystone habits, identity change, and why the most important part of taking a GLP-1 may be using the temporary window it creates to build habits that last after the me...
From the Archive: Garry Kasparov on Deep Blue, Fear, and the Future of AI
Former World Chess Champion Garry Kasparov on Deep Blue, AI, fear, resilience, and the skill that matters most when the world changes: adaptability.
Frank Miller on Push the Wall, Batman, and Having No Plan B
Frank Miller joins James for a conversation about Batman, Daredevil, mythology, discipline, mentorship, and the craft behind great comic book storytelling. They discuss The Dark Knight Returns, Daredevil, Ronin, Sin City, and Miller’s new book, Push the Wall, a memoir and guide to writing, drawing, ...
Dr. David Sinclair: The First Human Trial of an Age-Reversal Therapy
Dr. David Sinclair returns to discuss ER-100, the first partial epigenetic-reprogramming therapy to enter human clinical trials. He explains how three Yamanaka factors restored visual function in animal studies, why the first trial targets optic-nerve diseases, and what this could mean for treating ...
How to Find Sure Things on Kalshi | Prediction Markets #1
James explains how prediction markets work and the two kinds of informational advantage he looks for before placing a trade. Using markets involving government disclosures, SpaceX launches, presidential speech patterns, and TSA passenger volume, he shows how data can reveal a gap between the market ...
Zynga Founder Mark Pincus: Why All New Fails + How to Copy to Millions
Zynga founder Mark Pincus explains how to test demand before building, copy proven products intelligently, and use his “Proven–Better–New” framework to improve the odds of creating something people want. He also breaks down why Tribe failed, why consumer-app distribution is broken, and how AI agents...
From the Archive: The 7 Techniques to Influence Anyone of Anything | Robert Cialdini
In this From the Archive episode, James sits down with Dr. Robert Cialdini — the godfather of persuasion science and author of the three-million-copy bestseller Influence — to unpack the ideas behind his landmark follow-up, Pre-Suasion. The conversation centers on a deceptively simple question: What...
From the Archive: Your Money Blueprint: Why You Keep Earning and Losing the Same Amount | T. Harv Eker
Why do some people repeatedly earn money only to lose it again? In this early episode of The James Altucher Show, James talks with Secrets of the Millionaire Mind author T. Harv Eker about the unconscious “money blueprint” that shapes how much we earn, keep, and grow.
The Viral Chess Cheating Scandal with Anal Beads: Ben Mezrich Reveals the Full Story
James talks with Ben Mezrich about Checkmate, his new book on Magnus Carlsen, Hans Niemann, chess.com, and the cheating scandal that became a global obsession. They break down what may have happened, why the evidence remains murky, and how one chess game turned into lawsuits, viral rumors, and a bat...